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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732227
Species: Homo sapiens
RGD Object: Gene
Symbol: NR3C1
Name: nuclear receptor subfamily 3 group C member 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR3C1affects activityEXP 6480464CTDBenzo(a)pyrene affects the activity of NR3C1 proteinPMID:20624995
NR3C1decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of NR3C1 5' UTRPMID:27901495
NR3C1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of NR3C1 mRNAPMID:26238291
NR3C1multiple interactionsEXP 6480464CTDBenzo(a)pyrene affects the reaction [Dexamethasone affects the expression of NR3C1 mRNA]PMID:19463884
NR3C1increases expressionISONr3c1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of NR3C1 mRNAPMID:15034205
NR3C1multiple interactionsISONr3c1 (Mus musculus)6480464CTDAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of NR3C1 mRNA]PMID:15034205
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