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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730997
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC38A3
Name: solute carrier family 38 member 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC38A3affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of SLC38A3 intronPMID:30157460
SLC38A3decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of SLC38A3 mRNAPMID:20106945 PMID:32234424
SLC38A3decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of SLC38A3 promoterPMID:27901495
SLC38A3increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of SLC38A3 5' UTR; Benzo(a)pyrene results in increased methylation of SLC38A3 exonPMID:27901495
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