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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730822
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of MMP2 mRNAPMID:22369883 PMID:22610609 PMID:33429317
Mmp2multiple interactionsEXP 6480464CTD[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Benzo(a)pyrene] results in decreased expression of MMP2 mRNA; baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA]; Benzo(a)pyrene promotes the reaction [AHR protein binds to MMP2 promoter]PMID:19654925 PMID:22369883 PMID:33429317
Mmp2affects expressionISOMMP2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of MMP2 mRNAPMID:31154059
Mmp2affects methylationISOMMP2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of MMP2 3' UTR; Benzo(a)pyrene affects the methylation of MMP2 promoterPMID:27901495 PMID:30157460
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of MMP2 mRNAPMID:30659931
Mmp2increases expressionISOMmp2 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of MMP2 mRNAPMID:19022365
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of MMP2 proteinPMID:26359795
Mmp2increases methylationISOMMP2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of MMP2 3' UTR; Benzo(a)pyrene results in increased methylation of MMP2 exonPMID:27901495
Mmp2multiple interactionsISOMmp2 (Rattus norvegicus)6480464CTDalpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA]PMID:19022365
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the reaction [IL1B protein affects the expression of MMP2 mRNA]PMID:35405071
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