GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mmp2 | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of MMP2 mRNA | PMID:22369883 PMID:22610609 PMID:33429317 | Mmp2 | multiple interactions | EXP | | 6480464 | CTD | [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Benzo(a)pyrene] results in decreased expression of MMP2 mRNA; baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA]; Benzo(a)pyrene promotes the reaction [AHR protein binds to MMP2 promoter] | PMID:19654925 PMID:22369883 PMID:33429317 | Mmp2 | affects expression | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the expression of MMP2 mRNA | PMID:31154059 | Mmp2 | affects methylation | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of MMP2 3' UTR; Benzo(a)pyrene affects the methylation of MMP2 promoter | PMID:27901495 PMID:30157460 | Mmp2 | decreases expression | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of MMP2 mRNA | PMID:30659931 | Mmp2 | increases expression | ISO | Mmp2 (Rattus norvegicus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of MMP2 mRNA | PMID:19022365 | Mmp2 | increases expression | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of MMP2 protein | PMID:26359795 | Mmp2 | increases methylation | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of MMP2 3' UTR; Benzo(a)pyrene results in increased methylation of MMP2 exon | PMID:27901495 | Mmp2 | multiple interactions | ISO | Mmp2 (Rattus norvegicus) | 6480464 | CTD | alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA] | PMID:19022365 | Mmp2 | multiple interactions | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the reaction [IL1B protein affects the expression of MMP2 mRNA] | PMID:35405071 | |
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