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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsto1
Name: glutathione S-transferase omega 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsto1decreases expressionISOGSTO1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of GSTO1 mRNA; Benzo(a)pyrene results in decreased expression of GSTO1 proteinPMID:22138271 PMID:32234424
Gsto1decreases expressionISOGsto1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of GSTO1 mRNAPMID:22228805
Gsto1increases expressionISOGsto1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of GSTO1 mRNAPMID:20127859 PMID:23735875
Gsto1multiple interactionsISOGSTO1 (Homo sapiens)6480464CTDMethionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSTO1 protein]PMID:22138271
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