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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69473
Species: Homo sapiens
RGD Object: Gene
Symbol: SREBF1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SREBF1affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of SREBF1 promoterPMID:27901495
SREBF1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of SREBF1 mRNAPMID:18247414 PMID:20106945 PMID:21871943 PMID:22316170 PMID:26238291 PMID:32234424
SREBF1decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of SREBF1 3' UTRPMID:27901495
SREBF1increases mutagenesisEXP 6480464CTDBenzo(a)pyrene results in increased mutagenesis of SREBF1 genePMID:25435355
SREBF1multiple interactionsEXP 6480464CTDBenzo(a)pyrene inhibits the reaction [Estradiol inhibits the reaction [Oleic Acid results in increased expression of SREBF1 mRNA]]; Benzo(a)pyrene inhibits the reaction [Estradiol inhibits the reaction [Oleic Acid results in increased expression of SREBF1 protein]]PMID:31730885
SREBF1increases expressionISOSrebf1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of SREBF1 mRNAPMID:26303333
SREBF1multiple interactionsISOSrebf1 (Mus musculus)6480464CTDBenzo(a)pyrene affects the reaction [GCLM gene mutant form results in decreased expression of SREBF1 mRNA]; Benzo(a)pyrene promotes the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; Benzo(a)pyrene promotes the reaction [Dietary Fats results in increased expression of SREBF1 protein]PMID:24291350 PMID:31730885
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