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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69164
Species: Mus musculus
RGD Object: Gene
Symbol: Ifrd1
Name: interferon-related developmental regulator 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifrd1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of IFRD1 mRNAPMID:21569818
Ifrd1affects methylationISOIFRD1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of IFRD1 promoterPMID:27901495
Ifrd1decreases expressionISOIFRD1 (Homo sapiens)6480464CTDBenzo(a)pyrene metabolite results in decreased expression of IFRD1 mRNAPMID:24356939
Ifrd1increases expressionISOIFRD1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of IFRD1 mRNAPMID:21632981 PMID:26238291
Ifrd1increases methylationISOIFRD1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of IFRD1 5' UTR; Benzo(a)pyrene results in increased methylation of IFRD1 exonPMID:27901495
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