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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68650
Species: Mus musculus
RGD Object: Gene
Symbol: Pde10a
Name: phosphodiesterase 10A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pde10adecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of PDE10A mRNAPMID:19770486
Pde10aincreases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of PDE10A exon; Benzo(a)pyrene results in increased methylation of PDE10A intronPMID:27901495
Pde10adecreases expressionISOPde10a (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of PDE10A mRNAPMID:21839799
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