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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68640
Species: Homo sapiens
RGD Object: Gene
Symbol: IGFALS
Name: insulin like growth factor binding protein acid labile subunit
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGFALSaffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of IGFALS promoterPMID:27901495 PMID:30157460
IGFALSdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of IGFALS mRNAPMID:22316170
IGFALSdecreases expressionISOIgfals (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of IGFALS mRNAPMID:19770486 PMID:22228805
IGFALSmultiple interactionsISOIgfals (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to IGFALS promoter]PMID:19654925
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