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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68541
Species: Homo sapiens
RGD Object: Gene
Symbol: DPYS
Name: dihydropyrimidinase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DPYSaffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of DPYS intronPMID:30157460
DPYSdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of DPYS mRNAPMID:32234424
DPYSincreases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of DPYS exon; Benzo(a)pyrene results in increased methylation of DPYS promoterPMID:27901495
DPYSdecreases expressionISODpys (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of DPYS mRNAPMID:19770486
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