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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68385
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacnb4
Name: calcium voltage-gated channel auxiliary subunit beta 4
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacnb4affects methylationISOCACNB4 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CACNB4 intron; Benzo(a)pyrene affects the methylation of CACNB4 promoterPMID:27901495 PMID:30157460
Cacnb4decreases expressionISOCacnb4 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CACNB4 mRNAPMID:22228805
Cacnb4decreases methylationISOCacnb4 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of CACNB4 intronPMID:27901495
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