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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631432
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slu7
Name: SLU7 homolog, splicing factor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slu7decreases methylationISOSlu7 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of SLU7 exon; Benzo(a)pyrene results in decreased methylation of SLU7 intronPMID:27901495
Slu7increases expressionISOSLU7 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of SLU7 mRNAPMID:20064835
Slu7increases expressionISOSlu7 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of SLU7 mRNAPMID:22228805
Slu7increases methylationISOSLU7 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SLU7 promoterPMID:27901495
Slu7multiple interactionsISOSlu7 (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SLU7 mRNA]PMID:22228805
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