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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631363
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppm1f
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1F
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppm1faffects methylationISOPPM1F (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PPM1F promoterPMID:27901495
Ppm1fdecreases methylationISOPPM1F (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of PPM1F 3' UTR; Benzo(a)pyrene results in decreased methylation of PPM1F 5' UTRPMID:27901495
Ppm1fincreases expressionISOPPM1F (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of PPM1F mRNAPMID:19152381
Ppm1fincreases expressionISOPpm1f (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of PPM1F mRNAPMID:22610609
Ppm1fmultiple interactionsISOPPM1F (Homo sapiens)6480464CTDchlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of PPM1F mRNA]PMID:19152381
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