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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631340
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Snd1affects methylationISOSND1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SND1 intron; Benzo(a)pyrene affects the methylation of SND1 promoterPMID:27901495 PMID:30157460
Snd1decreases expressionISOSND1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of SND1 mRNA; Benzo(a)pyrene results in decreased expression of SND1 proteinPMID:20064835 PMID:33278487
Snd1decreases expressionISOSnd1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SND1 mRNAPMID:15034205 PMID:19770486 PMID:21715664
Snd1increases methylationISOSnd1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of SND1 intronPMID:27901495
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