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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 629472
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk5r1
Name: cyclin-dependent kinase 5 regulatory subunit 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk5r1multiple interactionsEXP 6480464CTDBenzo(a)pyrene results in increased expression of and results in increased cleavage of CDK5R1 proteinPMID:34529316
Cdk5r1decreases expressionISOCDK5R1 (Homo sapiens)6480464CTDBenzo(a)pyrene metabolite results in decreased expression of CDK5R1 mRNAPMID:26314263
Cdk5r1increases expressionISOCdk5r1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CDK5R1 mRNAPMID:19146932
Cdk5r1increases expressionISOCDK5R1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CDK5R1 mRNAPMID:32234424
Cdk5r1increases methylationISOCDK5R1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CDK5R1 5' UTR; Benzo(a)pyrene results in increased methylation of CDK5R1 promoterPMID:27901495
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