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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gjc1
Name: gap junction protein, gamma 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gjc1affects methylationISOGJC1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of GJC1 promoterPMID:27901495
Gjc1decreases expressionISOGJC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of GJC1 mRNAPMID:31255691
Gjc1decreases methylationISOGJC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of GJC1 5' UTR; Benzo(a)pyrene results in decreased methylation of GJC1 exonPMID:27901495
Gjc1increases expressionISOGjc1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of GJC1 mRNAPMID:22228805
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