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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h4affects methylationISONR1H4 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of NR1H4 promoterPMID:27901495
Nr1h4decreases expressionISONR1H4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of NR1H4 mRNAPMID:19737606 PMID:20106945 PMID:21632981 PMID:22316170 PMID:26238291 PMID:32234424
Nr1h4increases methylationISONR1H4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of NR1H4 5' UTRPMID:27901495
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