Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628596
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tubb5
Name: tubulin, beta 5 class I
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tubb5multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of TUBB5 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of TUBB5 mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of TUBB5 mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of TUBB5 mRNAPMID:18711122
Tubb5decreases expressionISOTUBB (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of TUBB mRNAPMID:20064835
Tubb5decreases expressionISOTubb5 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of TUBB5 mRNAPMID:15034205
Tubb5increases expressionISOTUBB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of TUBB mRNAPMID:32234424
Tubb5increases methylationISOTUBB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of TUBB 3' UTR; Benzo(a)pyrene results in increased methylation of TUBB promoterPMID:27901495
Tubb5multiple interactionsISOTubb5 (Mus musculus)6480464CTDAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of TUBB5 mRNA]PMID:15034205
Go Back to source page   Continue to Ontology report