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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62309
Species: Mus musculus
RGD Object: Gene
Symbol: Pebp1
Name: phosphatidylethanolamine binding protein 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pebp1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of PEBP1 mRNAPMID:22228805
Pebp1multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PEBP1 mRNAPMID:27858113
Pebp1decreases expressionISOPEBP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PEBP1 mRNAPMID:32234424
Pebp1increases methylationISOPEBP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PEBP1 3' UTR; Benzo(a)pyrene results in increased methylation of PEBP1 promoterPMID:27901495
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