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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621710
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pip4k2b
Name: phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pip4k2baffects methylationISOPIP4K2B (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PIP4K2B 3' UTR; Benzo(a)pyrene affects the methylation of PIP4K2B promoterPMID:27901495
Pip4k2bdecreases expressionISOPip4k2b (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of PIP4K2B mRNAPMID:19770486
Pip4k2bdecreases expressionISOPIP4K2B (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PIP4K2B mRNAPMID:26238291
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