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RGD ID: 621703
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxc2
Name: forkhead box C2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxc2affects methylationISOFOXC2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of FOXC2 exonPMID:27901495
Foxc2decreases methylationISOFOXC2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of FOXC2 promoterPMID:27901495
Foxc2increases expressionISOFoxc2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of FOXC2 mRNAPMID:22228805
Foxc2multiple interactionsISOFoxc2 (Mus musculus)6480464CTDBenzo(a)pyrene affects the reaction [AHR protein binds to FOXC2 promoter]PMID:19654925
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