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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nefl
Name: neurofilament light chain
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Neflaffects methylationISONEFL (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of NEFL exonPMID:27901495
Nefldecreases methylationISONEFL (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of NEFL 3' UTRPMID:27901495
Neflincreases expressionISONEFL (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of NEFL mRNAPMID:22316170 PMID:32234424
Neflincreases methylationISONEFL (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of NEFL 5' UTR; Benzo(a)pyrene results in increased methylation of NEFL promoterPMID:27901495
Neflmultiple interactionsISONefl (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to NEFL promoter]PMID:19654925
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