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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620918
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rab27a
Name: RAB27A, member RAS oncogene family
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rab27aaffects methylationISORAB27A (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of RAB27A 5' UTRPMID:27901495
Rab27adecreases expressionISORab27a (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of RAB27A mRNAPMID:15034205
Rab27aincreases expressionISORAB27A (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of RAB27A mRNAPMID:26238291
Rab27aincreases expressionISORab27a (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of RAB27A mRNAPMID:22228805
Rab27aincreases methylationISORAB27A (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of RAB27A promoterPMID:27901495
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