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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620878
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Phldb1
Name: pleckstrin homology-like domain, family B, member 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Phldb1affects methylationISOPHLDB1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PHLDB1 5' UTR; Benzo(a)pyrene affects the methylation of PHLDB1 exonPMID:27901495 PMID:30157460
Phldb1decreases expressionISOPhldb1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of PHLDB1 mRNAPMID:19770486
Phldb1increases expressionISOPHLDB1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of PHLDB1 mRNA; Benzo(a)pyrene results in increased expression of PHLDB1 proteinPMID:32234424 PMID:32717239
Phldb1increases expressionISOPhldb1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of PHLDB1 mRNAPMID:22228805
Phldb1increases methylationISOPHLDB1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PHLDB1 promoterPMID:27901495
Phldb1multiple interactionsISOPhldb1 (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PHLDB1 mRNA]PMID:22228805
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