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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620871
Species: Rattus norvegicus
RGD Object: Gene
Symbol: F2rl2
Name: coagulation factor II (thrombin) receptor-like 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2rl2increases expressionISOF2RL2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of F2RL2 mRNAPMID:20064835 PMID:32234424
F2rl2increases methylationISOF2RL2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of F2RL2 promoterPMID:27901495
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