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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620713
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgfr1
Name: Fibroblast growth factor receptor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgfr1decreases expressionISOFGFR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of FGFR1 mRNAPMID:22316170 PMID:26238291
Fgfr1increases expressionISOFGFR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of FGFR1 mRNAPMID:32234424
Fgfr1increases methylationISOFGFR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of FGFR1 5' UTR; Benzo(a)pyrene results in increased methylation of FGFR1 promoterPMID:27901495
Fgfr1increases mutagenesisISOFGFR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of FGFR1 genePMID:25435355
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