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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620573
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyba
Name: cytochrome b-245 alpha chain
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cybaaffects methylationISOCYBA (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CYBA promoterPMID:27901495
Cybadecreases expressionISOCYBA (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CYBA mRNAPMID:32234424 PMID:35690182
Cybadecreases expressionISOCyba (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CYBA mRNAPMID:19770486 PMID:22641617
Cybaincreases expressionISOCyba (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CYBA mRNAPMID:22228805
Cybaincreases methylationISOCYBA (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CYBA exonPMID:27901495
Cybamultiple interactionsISOCyba (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to CYBA promoter]PMID:19654925
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