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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620418
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fbxo6
Name: F-box protein 6
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fbxo6decreases methylationISOFBXO6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of FBXO6 5' UTRPMID:27901495
Fbxo6increases expressionISOFbxo6 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of FBXO6 mRNAPMID:22228805
Fbxo6increases methylationISOFBXO6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of FBXO6 promoterPMID:27901495
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