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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620269
Species: Rattus norvegicus
RGD Object: Gene
Symbol: P2ry6
Name: pyrimidinergic receptor P2Y6
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
P2ry6affects methylationISOP2RY6 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of P2RY6 5' UTR; Benzo(a)pyrene affects the methylation of P2RY6 intron; Benzo(a)pyrene affects the methylation of P2RY6 promoterPMID:27901495 PMID:30157460
P2ry6increases expressionISOP2ry6 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of P2RY6 mRNAPMID:22228805 PMID:23735875
P2ry6increases expressionISOP2RY6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of P2RY6 mRNAPMID:20064835 PMID:22316170
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