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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620131
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdh1
Name: 3-hydroxybutyrate dehydrogenase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdh1affects methylationISOBDH1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of BDH1 3' UTR; Benzo(a)pyrene affects the methylation of BDH1 promoterPMID:27901495
Bdh1decreases expressionISOBDH1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of BDH1 mRNAPMID:20106945 PMID:32234424
Bdh1decreases expressionISOBdh1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of BDH1 mRNAPMID:19770486
Bdh1increases expressionISOBdh1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of BDH1 mRNAPMID:22228805
Bdh1increases methylationISOBDH1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of BDH1 5' UTR; Benzo(a)pyrene results in increased methylation of BDH1 exonPMID:27901495
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