GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gclm | affects methylation | ISO | GCLM (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of GCLM promoter | PMID:27901495 | Gclm | affects response to substance | ISO | Gclm (Mus musculus) | 6480464 | CTD | GCLM protein affects the susceptibility to Benzo(a)pyrene | PMID:22253057 | Gclm | decreases expression | ISO | Gclm (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of GCLM mRNA | PMID:22228805 | Gclm | decreases response to substance | ISO | Gclm (Mus musculus) | 6480464 | CTD | GCLM gene mutant form results in decreased susceptibility to Benzo(a)pyrene | PMID:24291350 | Gclm | increases expression | ISO | GCLM (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of GCLM mRNA; Benzo(a)pyrene results in increased expression of GCLM protein | PMID:20064835 PMID:20106945 PMID:21632981 PMID:21871943 PMID:22316170 PMID:26198647 PMID:26238291 PMID:33278487 | Gclm | increases expression | ISO | Gclm (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of GCLM mRNA | PMID:15034205 PMID:15894712 PMID:19770486 PMID:21569818 PMID:21715664 | Gclm | increases response to substance | ISO | Gclm (Mus musculus) | 6480464 | CTD | GCLM gene mutant form results in increased susceptibility to Benzo(a)pyrene | PMID:23135907 PMID:28279692 | Gclm | multiple interactions | ISO | Gclm (Mus musculus) | 6480464 | CTD | [arsenite co-treated with Benzo(a)pyrene] results in increased expression of GCLM mRNA; [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GCLM mRNA; [GCLM gene mutant form results in decreased abundance of Glutathione] which results in decreased susceptibility to Benzo(a)pyrene; Benzo(a)pyrene affects the reaction [GCLM gene mutant form results in decreased expression of FASN mRNA]; Benzo(a)pyrene affects the reaction [GCLM gene mutant form results in decreased expression of SREBF1 mRNA]; Benzo(a)pyrene inhibits the reaction [GCLM gene mutant form results in increased expression of SOD2 mRNA]; GCLM gene mutant form promotes the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA] | PMID:15894712 PMID:24107266 PMID:24291350 PMID:25820237 | | ||||||||||||||||||||||
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