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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61975
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctla4
Name: cytotoxic T-lymphocyte-associated protein 4
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctla4affects response to substanceISORGD:7374656480464CTDCTLA4 gene SNP affects the susceptibility to Benzo(a)pyrene

PMID:28807506
Ctla4increases expressionISORGD:7374656480464CTDBenzo(a)pyrene results in increased expression of CTLA4 mRNA

PMID:22316170
Ctla4increases expressionISORGD:7374666480464CTDBenzo(a)pyrene results in increased expression of CTLA4 mRNA

PMID:22228805
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.