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RGD ID: 61957
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Isl1
Name: ISL LIM homeobox 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Isl1decreases methylationISOISL1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of ISL1 5' UTR; Benzo(a)pyrene results in decreased methylation of ISL1 promoterPMID:27901495
Isl1increases expressionISOISL1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ISL1 mRNAPMID:17879257 PMID:32234424
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