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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh3a2
Name: aldehyde dehydrogenase 3 family, member A2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh3a2decreases expressionISOALDH3A2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ALDH3A2 mRNAPMID:26238291
Aldh3a2increases expressionISOAldh3a2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ALDH3A2 mRNAPMID:19770486 PMID:20127859
Aldh3a2increases expressionISOALDH3A2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ALDH3A2 mRNAPMID:21802500
Aldh3a2increases methylationISOALDH3A2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ALDH3A2 promoterPMID:27901495
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