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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3127
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mx1
Name: MX dynamin like GTPase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mx1affects methylationISOMX1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of MX1 5' UTR; Benzo(a)pyrene affects the methylation of MX1 promoterPMID:27901495
Mx1decreases expressionISOMX1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of MX1 mRNAPMID:30453624
Mx1decreases expressionISOMx1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of MX1 mRNAPMID:20713471
Mx1increases expressionISOMX1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of MX1 mRNAPMID:19152381
Mx1increases expressionISOMx1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of MX1 mRNAPMID:11356909 PMID:23735875
Mx1increases methylationISOMX1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of MX1 exonPMID:27901495
Mx1multiple interactionsISOMX1 (Homo sapiens)6480464CTDchlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of MX1 mRNA]PMID:19152381
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