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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2958
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnj3
Name: potassium inwardly-rectifying channel, subfamily J, member 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj3affects methylationISOKCNJ3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of KCNJ3 promoterPMID:27901495
Kcnj3decreases expressionISOKCNJ3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of KCNJ3 mRNAPMID:32234424
Kcnj3decreases expressionISOKcnj3 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of KCNJ3 mRNAPMID:20127859 PMID:22228805
Kcnj3increases expressionISOKCNJ3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of KCNJ3 mRNAPMID:22316170
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