Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2906
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcr2
Name: C-X-C motif chemokine receptor 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr2affects methylationISOCXCR2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CXCR2 5' UTR; Benzo(a)pyrene affects the methylation of CXCR2 promoterPMID:27901495
Cxcr2decreases expressionISOCXCR2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CXCR2 mRNAPMID:18247414
Cxcr2decreases methylationISOCxcr2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of CXCR2 3' UTR; Benzo(a)pyrene results in decreased methylation of CXCR2 exonPMID:27901495
Cxcr2increases expressionISOCXCR2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CXCR2 mRNAPMID:21632981 PMID:32234424
Go Back to source page   Continue to Ontology report