GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of IL1B mRNA; Benzo(a)pyrene results in increased expression of IL1B protein | PMID:26358852 PMID:34999049 PMID:35378083 | Il1b | increases secretion | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased secretion of IL1B protein | PMID:20655936 | Il1b | multiple interactions | EXP | | 6480464 | CTD | [Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased expression of IL1B mRNA; [Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased expression of IL1B protein; [Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased secretion of IL1B protein; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; Benzo(a)pyrene promotes the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; Benzo(a)pyrene promotes the reaction [TNF protein results in increased expression of IL1B mRNA]; Dibutyl Phthalate promotes the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; IFNL3 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein] | PMID:20655936 PMID:21745554 PMID:34999049 PMID:35378083 PMID:36592837 | Il1b | affects expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the expression of IL1B mRNA | PMID:21873647 | Il1b | decreases methylation | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of IL1B 5' UTR | PMID:27901495 | Il1b | increases activity | ISO | Il1b (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased activity of IL1B protein | PMID:31702096 | Il1b | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of IL1B; Benzo(a)pyrene results in increased expression of IL1B mRNA; Benzo(a)pyrene results in increased expression of IL1B protein | PMID:21964900 PMID:22228805 PMID:22369883 PMID:30165701 PMID:31004597 PMID:32417428 PMID:32553695 | Il1b | increases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of IL1B mRNA; Benzo(a)pyrene results in increased expression of IL1B protein | PMID:14993811 PMID:15792794 PMID:15808406 PMID:17879257 PMID:20064835 PMID:21134426 PMID:28351761 PMID:30726812 PMID:32234424 PMID:35870112 | Il1b | increases secretion | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased secretion of IL1B protein | PMID:21447443 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | [Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Benzo(a)pyrene] results in increased expression of IL1B mRNA; baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; Benzo(a)pyrene inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Benzo(a)pyrene promotes the reaction [Dietary Fats results in increased expression of IL1B mRNA]; gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; limonin inhibits the reaction [Benzo(a)pyrene results in increased activity of IL1B protein]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B mRNA] | PMID:20412841 PMID:22369883 PMID:22466549 PMID:30165701 PMID:31004597 PMID:31702096 PMID:32553695 PMID:34998820 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; [Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of IL1B mRNA; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B mRNA]; Benzo(a)pyrene affects the reaction [IL1B protein affects the expression of CXCL8 mRNA]; Benzo(a)pyrene affects the reaction [IL1B protein affects the expression of ITGB1 mRNA]; Benzo(a)pyrene affects the reaction [IL1B protein affects the expression of MMP2 mRNA]; Benzo(a)pyrene promotes the reaction [IL1B protein results in increased expression of CYP1A1 mRNA]; beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; IGF1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; Quercetin inhibits the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]] | PMID:14993811 PMID:21447443 PMID:21453744 PMID:30726812 PMID:35405071 | | ||||||||||||||||||||||
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