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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2830
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hrh1
Name: histamine receptor H 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hrh1affects methylationISOHRH1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of HRH1 5' UTR; Benzo(a)pyrene affects the methylation of HRH1 promoterPMID:27901495
Hrh1decreases expressionISOHRH1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of HRH1 mRNAPMID:20064835
Hrh1decreases methylationISOHRH1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of HRH1 3' UTRPMID:27901495
Hrh1increases expressionISOHRH1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of HRH1 mRNAPMID:32234424
Hrh1increases methylationISOHrh1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of HRH1 intronPMID:27901495
Hrh1multiple interactionsISOHrh1 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to HRH1 promoter]PMID:19654925
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