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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2561
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb2affects methylationISOERBB2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ERBB2 5' UTRPMID:27901495
Erbb2decreases expressionISOERBB2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ERBB2 mRNAPMID:16269432 PMID:22316170 PMID:26238291
Erbb2increases expressionISOERBB2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ERBB2 proteinPMID:32717239
Erbb2increases methylationISOERBB2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ERBB2 promoterPMID:27901495
Erbb2multiple interactionsISOErbb2 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to ERBB2 promoter]PMID:19654925
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