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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2327
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpb
Name: CCAAT/enhancer binding protein beta
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpbdecreases expressionISOCebpb (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CEBPB mRNAPMID:22228805 PMID:27195522
Cebpbdecreases expressionISOCEBPB (Homo sapiens)6480464CTDBenzo(a)pyrene metabolite results in decreased expression of CEBPB mRNA; Benzo(a)pyrene results in decreased expression of CEBPB mRNAPMID:24356939 PMID:32234424
Cebpbincreases expressionISOCEBPB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CEBPB proteinPMID:32717239
Cebpbincreases methylationISOCEBPB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CEBPB promoterPMID:27901495
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