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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2321145
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fbxw7
Name: F-box and WD repeat domain containing 7
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fbxw7affects methylationISOFBXW7 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of FBXW7 5' UTRPMID:27901495
Fbxw7decreases expressionISOFBXW7 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of FBXW7 mRNAPMID:20064835
Fbxw7decreases expressionISOFbxw7 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of FBXW7 mRNAPMID:19770486
Fbxw7increases expressionISOFBXW7 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of FBXW7 mRNAPMID:22316170 PMID:32234424
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