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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2171
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp1b2
Name: ATPase Na+/K+ transporting subunit beta 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp1b2increases expressionISOATP1B2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ATP1B2 mRNAPMID:20064835
Atp1b2increases methylationISOATP1B2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ATP1B2 exon; Benzo(a)pyrene results in increased methylation of ATP1B2 promoterPMID:27901495
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