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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2130
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apoa1
Name: apolipoprotein A1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoa1affects methylationISOAPOA1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of APOA1 promoterPMID:27901495
Apoa1decreases expressionISOAPOA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of APOA1 mRNA; Benzo(a)pyrene results in decreased expression of APOA1 proteinPMID:22727790 PMID:32234424 PMID:33278487
Apoa1increases expressionISOApoa1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of APOA1 mRNAPMID:22228805
Apoa1increases methylationISOAPOA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of APOA1 3' UTRPMID:27901495
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