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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1622934
Species: Mus musculus
RGD Object: Gene
Symbol: Ints6l
Name: integrator complex subunit 6 like
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ints6lincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of INTS6L mRNAPMID:22228805
Ints6laffects methylationISOINTS6L (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of DDX26B 3' UTR; Benzo(a)pyrene affects the methylation of DDX26B promoterPMID:27901495
Ints6lincreases methylationISOINTS6L (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of DDX26B 5' UTRPMID:27901495
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