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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621180
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnf1
Name: potassium voltage-gated channel, subfamily F, member 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnf1multiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to KCNF1 promoter]PMID:19654925
Kcnf1affects methylationISOKCNF1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of KCNF1 3' UTR; Benzo(a)pyrene affects the methylation of KCNF1 exon; Benzo(a)pyrene affects the methylation of KCNF1 promoterPMID:27901495
Kcnf1increases expressionISOKCNF1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of KCNF1 mRNAPMID:20064835
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