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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1618254
Species: Mus musculus
RGD Object: Gene
Symbol: Pik3r6
Name: phosphoinositide-3-kinase regulatory subunit 5
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3r6increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of PIK3R6 mRNAPMID:22228805
Pik3r6affects methylationISOPIK3R6 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PIK3R6 intron; Benzo(a)pyrene affects the methylation of PIK3R6 promoterPMID:27901495 PMID:30157460
Pik3r6decreases expressionISOPIK3R6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PIK3R6 mRNAPMID:20106945
Pik3r6increases methylationISOPIK3R6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PIK3R6 5' UTRPMID:27901495
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