Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1607087
Species: Homo sapiens
RGD Object: Gene
Symbol: PIGA
Name: phosphatidylinositol glycan anchor biosynthesis class A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PIGAaffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of PIGA 5' UTR; Benzo(a)pyrene affects the methylation of PIGA promoterPMID:27901495
PIGAdecreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of PIGA 3' UTRPMID:27901495
PIGAincreases mutagenesisEXP 6480464CTDBenzo(a)pyrene results in increased mutagenesis of PIGA genePMID:28461126
PIGAincreases mutagenesisISOPiga (Mus musculus)6480464CTDBenzo(a)pyrene results in increased mutagenesis of PIGA genePMID:24105957 PMID:28111842
PIGAincreases mutagenesisISOPiga (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased mutagenesis of PIGA; Benzo(a)pyrene results in increased mutagenesis of PIGA genePMID:20202993 PMID:22052432 PMID:22923490
PIGAmultiple interactionsISOPiga (Mus musculus)6480464CTDPOR protein affects the reaction [Benzo(a)pyrene results in increased mutagenesis of PIGA gene]PMID:28111842
PIGAmultiple interactionsISOPiga (Rattus norvegicus)6480464CTD[Benzo(a)pyrene results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Benzo(a)pyrene results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein; Benzo(a)pyrene results in increased mutagenesis of and results in decreased activity of PIGA proteinPMID:19965957 PMID:20202993 PMID:27931811
Go Back to source page   Continue to Ontology report