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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1594557
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cfp
Name: complement factor properdin
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cfpaffects methylationISOCFP (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CFP promoterPMID:27901495
Cfpdecreases methylationISOCFP (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of CFP 5' UTR; Benzo(a)pyrene results in decreased methylation of CFP exonPMID:27901495
Cfpincreases expressionISOCFP (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CFP mRNAPMID:20064835
Cfpincreases mutagenesisISOCFP (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of CFP genePMID:25435355
Cfpmultiple interactionsISOCfp (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CFP mRNA]PMID:22228805
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