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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1594556
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfaip2
Name: TNF alpha induced protein 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of TNFAIP2 mRNA

PMID:21839799
affects methylationISORGD:13122346480464CTDBenzo(a)pyrene affects the methylation of TNFAIP2 intron

PMID:30157460
increases expressionISORGD:13122346480464CTDBenzo(a)pyrene results in increased expression of TNFAIP2 mRNA

PMID:22316170
increases expressionISORGD:13122356480464CTDBenzo(a)pyrene results in increased expression of TNFAIP2 mRNA

PMID:14625279, PMID:19770486, PMID:21995607, PMID:22228805
multiple interactionsISORGD:13122356480464CTD[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of TNFAIP2 mRNA], AHR affects the reaction [Benzo(a)pyrene results in increased expression of TNFAIP2 mRNA], Benzo(a)pyrene promotes the reaction [AHR protein binds to TNFAIP2 promoter]

PMID:14625279, PMID:21995607
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.