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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1586637
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ryr1
Name: ryanodine receptor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ryr1affects methylationISORYR1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of RYR1 intron; Benzo(a)pyrene affects the methylation of RYR1 promoterPMID:27901495 PMID:30157460
Ryr1decreases expressionISORyr1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of RYR1 mRNAPMID:22228805
Ryr1multiple interactionsISORyr1 (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of RYR1 mRNA]PMID:22228805
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